"Scientific References - הרוקח הגלילי"
Scientific References
المراجع العلمية الكاملة
מקורות מדעיים מלאים
Supporting both editions of:
"הרוקח הגלילי" (Hebrew) | "الصيدلي الجليلي" (Arabic)
Dr. Ziad Dabour · Dr. Dabour Laboratories, Beit Jann, Galilee
"הרוקח הגלילי" (Hebrew) | "الصيدلي الجليلي" (Arabic)
Dr. Ziad Dabour · Dr. Dabour Laboratories, Beit Jann, Galilee
This bibliography provides evidence-based scientific references for 46 medicinal plants traditionally used in Galilean and Levantine folk medicine. All references are peer-reviewed and sourced from:
- European Medicines Agency (EMA/HMPC) official monographs
- Cochrane systematic reviews and meta-analyses
- Randomized controlled trials (RCTs)
- ESCOP, WHO, and German Commission E monographs
- Validated phytochemical and pharmacological studies
Evidence Level Key (used throughout the book):
🟢 = Confirmed by multiple RCTs, Cochrane reviews, or official EMA/ESCOP monographs
🟡 = Documented traditional use supported by laboratory or preliminary clinical evidence
⚪ = Traditional knowledge — further clinical research needed
🟢 = Confirmed by multiple RCTs, Cochrane reviews, or official EMA/ESCOP monographs
🟡 = Documented traditional use supported by laboratory or preliminary clinical evidence
⚪ = Traditional knowledge — further clinical research needed
Plant References A–Z
1. Aloe Vera (Aloe vera / Aloe barbadensis)
ع: الألوفيرا | ע: אלוורה
- European Medicines Agency. Assessment report on Aloe barbadensis Miller. EMA/HMPC/759585/2015. 2017.
- Dat AD, Poon F, Pham KB, Doust J. Aloe vera for treating acute and chronic wounds. Cochrane Database Syst Rev. 2012;2012(2):CD008762. doi:10.1002/14651858.CD008762.pub2
- Reuter J, Merfort I, Schempp CM. Botanicals in dermatology: an evidence-based review. Am J Clin Dermatol. 2010;11(4):247-267. doi:10.2165/11533220-000000000-00000
- Foster M, Hunter D, Samman S. Evaluation of the nutritional and metabolic effects of Aloe vera. In: Herbal Medicine: Biomolecular and Clinical Aspects. 2nd ed. CRC Press; 2011. Chapter 3.
- Natural Medicines Database. Aloe vera. Stockton: Therapeutic Research Faculty; 2023.
2. Apple (Malus domestica)
ع: التفاح | ע: תפוח
Note: Evidence distinguishes between raw apple (pectin → laxative effect) and cooked/dried apple (tannins → antidiarrheal). These are opposing actions explained by food chemistry, not a contradiction.
- Boyer J, Liu RH. Apple phytochemicals and their health benefits. Nutr J. 2004;3:5. doi:10.1186/1475-2891-3-5
- Hyson DA. A comprehensive review of apples and their relationship to human health. Adv Nutr. 2011;2(5):408-420. doi:10.3945/an.111.000513
- Koutsos A, Tuohy KM, Lovegrove JA. Apples and cardiovascular health. Nutrients. 2015;7(6):3959-3998. doi:10.3390/nu7063959
- Chai SC et al. Daily apple versus dried plum: impact on cardiovascular risk factors in postmenopausal women. J Acad Nutr Diet. 2012;112(8):1158-1168. doi:10.1016/j.jand.2012.05.005
- Denis MC et al. Apple peel polyphenols and their beneficial actions on oxidative stress. PLoS One. 2013;8(1):e53725. doi:10.1371/journal.pone.0053725
3. Basil (Ocimum basilicum)
ع: الريحان | ע: בזיליקום
- Fandohan P et al. Toxicity and gastric tolerance of essential oils from Ocimum species. Food Chem Toxicol. 2008;46(7):2493-2497. doi:10.1016/j.fct.2008.04.006
- Jamshidi N, Cohen MM. The clinical efficacy and safety of Tulsi in humans: a systematic review. Evid Based Complement Alternat Med. 2017;2017:9217567. doi:10.1155/2017/9217567
- Pandey AK, Singh P, Tripathi NN. Chemistry and bioactivities of essential oils of Ocimum species. Asian Pac J Trop Biomed. 2014;4(9):682-694. doi:10.12980/APJTB.4.2014C77
4. Bay Leaf (Laurus nobilis)
ع: الغار | ע: עלי דפנה
- Sayyah M et al. Analgesic and anti-inflammatory activity of the leaf essential oil of Laurus nobilis. Phytother Res. 2003;17(7):733-736. doi:10.1002/ptr.1197
- Sangun MK et al. Comparison of chemical composition of the essential oil of Laurus nobilis L. leaves. J Environ Biol. 2007;28(4):731-733.
- Fang F et al. Isolation and identification of cytotoxic compounds from Bay leaf. Food Chem. 2005;93(3):497-501. doi:10.1016/j.foodchem.2004.10.029
5. Carob (Ceratonia siliqua)
ع: الخروب | ע: חרוב
- Bengoechea C et al. Composition and structure of carob germ proteins. Food Chem. 2008;107(2):675-683. doi:10.1016/j.foodchem.2007.08.069
- Rtibi K et al. Gastroprotective effect of carob against ethanol-induced oxidative stress in rat. BMC Complement Altern Med. 2015;15:292. doi:10.1186/s12906-015-0821-9
- Loeb H et al. Tannin-rich carob pod for the treatment of acute-onset diarrhea. J Pediatr Gastroenterol Nutr. 1989;8(4):480-485.
6. Chamomile (Matricaria chamomilla)
ع: البابونج | ע: בבונג
- European Medicines Agency. Assessment report on Matricaria recutita L., flos. EMA/HMPC/55837/2011. 2013.
- Mao JJ et al. Long-term chamomile treatment for generalized anxiety disorder: a randomized clinical trial. Phytomedicine. 2016;23(14):1735-1742. doi:10.1016/j.phymed.2016.10.012
- Keefe JR et al. Short-term chamomile therapy of moderate to severe generalized anxiety disorder. Phytomedicine. 2016;23(14):1699-1705. doi:10.1016/j.phymed.2016.10.013
- Commission E. Matricariae flos. Bundesanzeiger 1984;228.
- ESCOP Monographs: Matricariae flos (Chamomile flower). 2nd ed. Stuttgart: Thieme; 2003.
7. Chaste Tree (Vitex agnus-castus)
ع: الفيتيكس | ע: אברהם אבינו
- European Medicines Agency. Assessment report on Vitex agnus-castus L., fructus. EMA/HMPC/74502/2010. 2012.
- Schellenberg R. Treatment for the premenstrual syndrome with agnus castus fruit extract: prospective, randomised, placebo controlled study. BMJ. 2001;322(7279):134-137. doi:10.1136/bmj.322.7279.134
- Milewicz A et al. Vitex agnus castus extract in the treatment of luteal phase defects. Arzneimittelforschung. 1993;43(7):752-756.
- ESCOP Monographs: Agni casti fructus. 2nd ed. Stuttgart: Thieme; 2003.
- Commission E. Agni casti fructus. Bundesanzeiger 1992;226.
8. Chicory (Cichorium intybus)
ع: الهندباء | ע: עולש
- Street RA, Sidana J, Prinsloo G. Cichorium intybus: traditional uses, phytochemistry, pharmacology. Evid Based Complement Alternat Med. 2013;2013:579319. doi:10.1155/2013/579319
- Saeed M et al. Chicory herb: chemical composition, pharmacology, nutritional applications. Int J Pharmacol. 2017;13(4):351-360. doi:10.3923/ijp.2017.351.360
- Pushparaj PN et al. Anti-diabetic effects of Cichorium intybus in streptozotocin-induced diabetic rats. J Ethnopharmacol. 2007;111(2):430-434. doi:10.1016/j.jep.2006.11.028
9. Cinnamon (Cinnamomum spp.)
ع: القرفة | ע: קינמון
- Leach MJ, Kumar S. Cinnamon for diabetes mellitus. Cochrane Database Syst Rev. 2012;2012(9):CD007170. doi:10.1002/14651858.CD007170.pub2
- Ranasinghe P et al. Efficacy and safety of Cinnamomum zeylanicum as a pharmaceutical agent in diabetes: a systematic review and meta-analysis. Diabet Med. 2012;29(12):1480-1492. doi:10.1111/j.1464-5491.2012.03718.x
10. Clove (Syzygium aromaticum)
ع: القرنفل | ע: ציפורן
- Cortés-Rojas DF et al. Clove: a precious spice. Asian Pac J Trop Biomed. 2014;4(2):90-96. doi:10.1016/S2221-1691(14)60215-X
- Alqareer A, Alyahya A, Andersson L. The effect of clove versus placebo as topical anesthetic. J Dent. 2006;34(10):747-750. doi:10.1016/j.jdent.2006.01.009
- Barboza JN et al. An overview on the anti-inflammatory potential of eugenol. Oxid Med Cell Longev. 2018;2018:3957262. doi:10.1155/2018/3957262
- Chaieb K et al. The chemical composition and biological activity of clove essential oil. Phytother Res. 2007;21(6):501-506. doi:10.1002/ptr.2124
11. Coffee (Coffea arabica / Coffea canephora)
ع: القهوة | ע: קפה
Note: All references below relate to oral coffee consumption. No controlled clinical evidence currently supports topical coffee application.
- Poole R et al. Coffee consumption and health: umbrella review of meta-analyses of multiple health outcomes. BMJ. 2017;359:j5024. doi:10.1136/bmj.j5024
- Ding M et al. Caffeinated and decaffeinated coffee consumption and risk of type 2 diabetes: a systematic review. Diabetes Care. 2014;37(2):569-586. doi:10.2337/dc13-1203
- Grosso G et al. Coffee, caffeine, and health outcomes: an umbrella review. Annu Rev Nutr. 2017;37:131-156. doi:10.1146/annurev-nutr-071816-064941
- Turnbull D et al. Caffeine and cardiovascular health. Regul Toxicol Pharmacol. 2017;89:165-185. doi:10.1016/j.yrtph.2017.07.025
12. Fennel (Foeniculum vulgare)
ع: الشمر | ע: שומר
- European Medicines Agency. Assessment report on Foeniculum vulgare Miller, fructus. EMA/HMPC/137428/2013. 2014.
- Alexandrovich I et al. The effect of fennel seed oil emulsion in infantile colic: a randomized, placebo-controlled study. Altern Ther Health Med. 2003;9(4):58-61.
- ESCOP Monographs: Foeniculi fructus (Fennel fruit). 2nd ed. Stuttgart: Thieme; 2003.
- Commission E. Foeniculi fructus. Bundesanzeiger 1990;162.
13. Fenugreek (Trigonella foenum-graecum)
ع: الحلبة | ע: חלבה
- Neelakantan N et al. Effect of fenugreek (Trigonella foenum-graecum L.) intake on glycemia: a meta-analysis of clinical trials. Nutr J. 2014;13:7. doi:10.1186/1475-2891-13-7
- Turkyılmaz C et al. The effect of galactagogue herbal tea on breast milk production. J Altern Complement Med. 2011;17(2):139-142. doi:10.1089/acm.2010.0090
- Roberts KT. The potential of fenugreek as a functional food and nutraceutical and its effects on glycemia and lipidemia. J Med Food. 2011;14(12):1485-1489. doi:10.1089/jmf.2011.0002
14. Garlic (Allium sativum)
ع: الثوم | ע: שום
- Ried K et al. Effect of garlic on blood pressure: a systematic review and meta-analysis. BMC Cardiovasc Disord. 2008;8:13. doi:10.1186/1471-2261-8-13
- Stabler SN et al. Garlic for the prevention of cardiovascular morbidity and mortality in hypertensive patients. Cochrane Database Syst Rev. 2012;2012(8):CD007653. doi:10.1002/14651858.CD007653.pub2
- Williamson EM, Driver S, Baxter K. Garlic + Warfarin and related drugs. In: Stockley's Herbal Medicines Interactions. 2nd ed. London: Pharmaceutical Press; 2013:181-184.
- Commission E. Allii sativi bulbus. Bundesanzeiger 1988;164.
15. Geranium (Pelargonium spp.)
ع: الجيرانيوم | ע: פלרגוניום
P. sidoides (Umckaloabo):
- Matthys H et al. Efficacy and safety of EPs 7630 in adults with acute bronchitis: a randomised, double-blind, placebo-controlled trial. Phytomedicine. 2003;10 Suppl 4:7-17. doi:10.1078/1433-187x-00309
- Timmer A et al. Pelargonium sidoides extract for treating acute respiratory tract infections. Cochrane Database Syst Rev. 2013;(10):CD006323. doi:10.1002/14651858.CD006323.pub3
P. graveolens (Rose Geranium):
- Boukhatem MN et al. Rose geranium essential oil as a source of new anti-inflammatory agents. Libyan J Med. 2013;8:22520. doi:10.3402/ljm.v8i0.22520
16. Ginger (Zingiber officinale)
ع: الزنجبيل | ע: זנגביל
- Ernst E, Pittler MH. Efficacy of ginger for nausea and vomiting: a systematic review of randomized clinical trials. Br J Anaesth. 2000;84(3):367-371. doi:10.1093/oxfordjournals.bja.a013442
- Altman RD, Marcussen KC. Effects of a ginger extract on knee pain in patients with osteoarthritis. Arthritis Rheum. 2001;44(11):2531-2538. doi:10.1002/1529-0131(200111)44:11<2531::aid-art433>3.0.co;2-j
- Commission E. Zingiberis rhizoma. Bundesanzeiger 1988;228.
17. Grape (Vitis vinifera)
ع: العنب | ע: ענב / גפן
- Kar P et al. Effects of grape seed extract in Type 2 diabetic subjects at high cardiovascular risk: a double blind randomized placebo controlled trial. Diabet Med. 2009;26(5):526-531. doi:10.1111/j.1464-5491.2009.02727.x
- Sivaprakasapillai B et al. Effect of grape seed extract on blood pressure in subjects with the metabolic syndrome. Metabolism. 2009;58(12):1743-1746. doi:10.1016/j.metabol.2009.05.030
- Feringa HH et al. The effect of grape seed extract on cardiovascular risk markers: a meta-analysis of randomized controlled trials. J Am Diet Assoc. 2011;111(8):1173-1181. doi:10.1016/j.jada.2011.05.015
18. Hawthorn (Crataegus monogyna / laevigata)
ع: الزعرور | ע: עוזרר
- European Medicines Agency. Assessment report on Crataegus spp., folium cum flore. EMA/HMPC/159075/2014. 2016.
- Pittler MH, Schmidt K, Ernst E. Hawthorn extract for treating chronic heart failure: meta-analysis of randomized trials. Am J Med. 2003;114(8):665-674. doi:10.1016/s0002-9343(03)00131-1
- Holubarsch CJ et al. The efficacy and safety of Crataegus extract WS 1442 in patients with heart failure: the SPICE trial. Eur J Heart Fail. 2008;10(12):1255-1263. doi:10.1016/j.ejheart.2008.10.004
- Commission E. Crataegi folium cum flore. Bundesanzeiger 1994;133.
- ESCOP Monographs: Crataegi folium cum flore (Hawthorn leaf and flower). 2nd ed. Stuttgart: Thieme; 2003.
19. Jasmine (Jasminum spp.)
ع: الياسمين | ע: יסמין
- Kuroda K et al. Sedative effects of the jasmine tea odor and linalool on autonomic nerve activity and mood states. Eur J Appl Physiol. 2005;95(2-3):107-114. doi:10.1007/s00421-005-1402-8
- Haze S, Sakai K, Gozu Y. Effects of fragrance inhalation on sympathetic activity in normal adults. Jpn J Pharmacol. 2002;90(3):247-253. doi:10.1254/jjp.90.247
20. Lavender (Lavandula angustifolia)
ع: الخزامى | ע: לבנדר
Note: References 2 and 3 relate to Silexan, a standardised pharmaceutical oral lavender oil preparation — not home-brewed tea. The proven anxiolytic effect applies specifically to this standardised product.
- European Medicines Agency. Assessment report on Lavandula angustifolia Miller. EMA/HMPC/143183/2010. 2012.
- Kasper S et al. Silexan, an orally administered Lavandula oil preparation, is effective in 'subsyndromal' anxiety disorder: a randomized, double-blind, placebo controlled trial. Int Clin Psychopharmacol. 2010;25(5):277-287. doi:10.1097/YIC.0b013e32833b3242
- Woelk H, Schläfke S. A multi-center, double-blind, randomised study of Silexan in comparison to Lorazepam for generalized anxiety disorder. Phytomedicine. 2010;17(2):94-99. doi:10.1016/j.phymed.2009.10.006
- ESCOP Monographs: Lavandulae flos (Lavender flower). 2nd ed. Stuttgart: Thieme; 2003.
21. Lemon Balm (Melissa) (Melissa officinalis)
ع: المليسة / الترنجان | ע: מליסה
Note: Available clinical evidence (Cases 2011, Kennedy 2003) is preliminary — small samples or single-dose designs. Evidence level is 🟡, not 🟢.
- European Medicines Agency. Assessment report on Melissa officinalis L., folium. EMA/HMPC/196745/2012. 2013.
- Cases J et al. Pilot trial of Melissa officinalis leaf extract in volunteers suffering from mild-to-moderate anxiety disorders and sleep disturbances. Med J Nutrition Metab. 2011;4(3):211-218. doi:10.1007/s12349-010-0045-4
- Kennedy DO et al. Modulation of mood and cognitive performance following acute administration of Melissa officinalis. Neuropsychopharmacology. 2003;28(10):1871-1881. doi:10.1038/sj.npp.1300230
- Commission E. Melissae folium. Bundesanzeiger 1984;43.
22. Lemon Verbena (Aloysia citrodora)
ع: فيربينا الليمون | ע: ורבנה לימונית
Note: Clinical evidence is limited. Use is based primarily on phytochemical composition and traditional practice in the Mediterranean region.
- Carnat A et al. The aromatic and polyphenolic composition of lemon verbena tea. Fitoterapia. 1999;70(1):44-49. doi:10.1016/S0367-326X(98)00017-2
23. Mallow (Malva sylvestris)
ع: الخبيز | ע: חלמית
- European Medicines Agency. Assessment report on Malva sylvestris L. EMA/HMPC/29388/2015. 2016.
- Gasparetto JC et al. Ethnobotanical and scientific aspects of Malva sylvestris L.: a millennial herbal medicine. J Pharm Pharmacol. 2012;64(2):172-189. doi:10.1111/j.2042-7158.2011.01383.x
- ESCOP Monographs: Malvae folium (Mallow leaf). 2nd ed. Stuttgart: Thieme; 2003.
24. Marjoram (Origanum majorana)
ع: المردقوش | ע: מיורן
- Vági E et al. Essential oil composition and antimicrobial activity of Origanum majorana L. extracts. Food Res Int. 2005;38(1):51-57. doi:10.1016/j.foodres.2004.07.006
- El-Ashmawy IM et al. Protective effect of volatile oil of Origanum majorana on lead acetate toxicity in mice. Basic Clin Pharmacol Toxicol. 2005;97(4):238-243. doi:10.1111/j.1742-7843.2005.pto_136.x
25. Mastic (Pistacia lentiscus)
ع: المصطكى | ע: שרף הלנטיסקוס
- Kaliora AC, Dedoussis GV, Schmidt H. Dietary antioxidants in preventing atherogenesis. Atherosclerosis. 2006;187(1):1-17. doi:10.1016/j.atherosclerosis.2005.11.001
- Huwez FU et al. Mastic gum kills Helicobacter pylori. N Engl J Med. 1998;339(26):1946. doi:10.1056/nejm199812243392618
- Dabos KJ et al. The effect of mastic gum on Helicobacter pylori: a randomized pilot study. Phytomedicine. 2010;17(3-4):296-299. doi:10.1016/j.phymed.2009.09.010
26. Milk Thistle (Silybum marianum)
ع: شوك مريم | ע: גדילן מצוי
- European Medicines Agency. Assessment report on Silybum marianum (L.) Gaertn., fructus. EMA/HMPC/294187/2013. 2015.
- Abenavoli L et al. Milk thistle in liver diseases: past, present, future. Phytother Res. 2010;24(10):1423-1432. doi:10.1002/ptr.3207
- ESCOP Monographs: Silybi mariani fructus (Milk thistle fruit). 2nd ed. Stuttgart: Thieme; 2003.
- Commission E. Silybi mariani fructus. Bundesanzeiger 1986;173.
27. Myrtle (Myrtus communis)
ع: الآس | ע: הדס
- Aleksic V, Knezevic P. Antimicrobial and antioxidative activity of extracts and essential oils of Myrtus communis L. Microbiol Res. 2014;169(4):240-254. doi:10.1016/j.micres.2013.10.003
- Gortzi O et al. Reevaluation of bioactivity and antioxidant activity of Myrtus communis extract before and after encapsulation in liposomes. Eur Food Res Technol. 2008;226(3):583-590.
28. Nigella / Black Seed (Nigella sativa)
ع: الحبة السوداء | ע: קצח
- Tavakkoli A et al. Review on clinical trials of black seed (Nigella sativa) and its active constituent, thymoquinone. J Pharmacopuncture. 2017;20(3):179-193. doi:10.3831/KPI.2017.20.021
- Sahebkar A et al. Nigella sativa oil and thymoquinone: overview on analgesic and anti-inflammatory effects. Front Pharmacol. 2018;9:1180. doi:10.3389/fphar.2018.01180
- Ahmad A et al. A review on therapeutic potential of Nigella sativa: a miracle herb. Asian Pac J Trop Biomed. 2013;3(5):337-352. doi:10.1016/S2221-1691(13)60075-1
29. Oak (Quercus spp.)
ع: البلوط | ע: אלון
- Rakić S et al. Oak acorn, polyphenols and antioxidant activity in functional food. J Food Eng. 2006;74(3):416-423. doi:10.1016/j.jfoodeng.2005.03.057
- European Medicines Agency. Assessment report on Quercus spp., cortex. EMA/HMPC/440856/2015. 2016.
30. Olive Leaf (Olea europaea)
ع: أوراق الزيتون | ע: עלי זית
- Lockyer S et al. Impact of phenolic-rich olive leaf extract on blood pressure, plasma lipids and inflammatory markers: a randomised controlled trial. Eur J Nutr. 2017;56(4):1421-1432. doi:10.1007/s00394-016-1188-y
- Susalit E et al. Olive leaf extract effective in patients with stage-1 hypertension: comparison with Captopril. Phytomedicine. 2011;18(4):251-258. doi:10.1016/j.phymed.2010.08.016
- Wainstein J et al. Olive leaf extract as a hypoglycemic agent in both human diabetic subjects and in rats. J Nutr Biochem. 2012;23(7):832-836. doi:10.1016/j.jnutbio.2011.04.012
31. Oregano / Galilean Thyme (Origanum syriacum)
ع: الزعتر الجليلي | ע: אזוב מצוי
- ESCOP Monographs: The Scientific Foundation for Herbal Medicinal Products. 2nd ed. Stuttgart: Thieme; 2003.
- Baser KH. Biological and pharmacological activities of carvacrol and carvacrol bearing essential oils. Curr Pharm Des. 2008;14(29):3106-3119. doi:10.2174/138161208786404227
- Force M, Sparks WS, Ronzio RA. Inhibition of enteric parasites by emulsified oil of oregano in vivo. Phytother Res. 2000;14(3):213-214. doi:10.1002/(sici)1099-1573(200005)14:3<213::aid-ptr583>3.0.co;2-u
32. Salep / Orchid (Orchis spp.)
ع: السالب | ע: סחלב
Note: References below document nutritional and food science properties only. No controlled clinical evidence exists for therapeutic applications.
- Benvenuto M et al. Salep: a traditional Turkish drink with nutritional and functional properties. Food Funct. 2017;8(10):3464-3472. doi:10.1039/c7fo00693d
- Tamer CE, Karaman B, Çopur Ö. A traditional Turkish beverage: Salep. Food Rev Int. 2006;22(1):43-50. doi:10.1080/87559120500379902
33. Peppermint (Mentha × piperita)
ع: النعناع | ע: נענע
Note: Peppermint oil capsules are evidence-based for IBS (🟢). However, peppermint tea/inhalation may worsen GERD by relaxing the lower esophageal sphincter — these are distinct mechanisms.
- European Medicines Agency. Assessment report on Mentha x piperita L., folium. EMA/HMPC/349653/2015. 2017.
- Khanna R, MacDonald JK, Levesque BG. Peppermint oil for the treatment of irritable bowel syndrome: a systematic review and meta-analysis. J Clin Gastroenterol. 2014;48(6):505-512. doi:10.1097/MCG.0b013e3182a88357
- ESCOP Monographs: Menthae piperitae folium (Peppermint leaf). 2nd ed. Stuttgart: Thieme; 2003.
- Commission E. Menthae piperitae folium. Bundesanzeiger 1990;43.
34. Pomegranate Peel (Punica granatum)
ع: قشور الرمان | ע: קליפת רימון
- Ismail T, Sestili P, Akhtar S. Pomegranate peel and fruit extracts: a review of potential anti-inflammatory and anti-infective effects. J Ethnopharmacol. 2012;143(2):397-405. doi:10.1016/j.jep.2012.07.004
- Al-Zoreky NS. Antimicrobial activity of pomegranate fruit peels. Int J Food Microbiol. 2009;134(3):244-248. doi:10.1016/j.ijfoodmicro.2009.07.002
35. Purslane (Portulaca oleracea)
ع: الفرفحينا | ע: רגלת הגינה
- Uddin MK et al. Purslane weed: a prospective plant source of nutrition, omega-3 fatty acid, and antioxidant attributes. ScientificWorldJournal. 2014;2014:951019. doi:10.1155/2014/951019
- El-Sayed MI. Effects of Portulaca oleracea seeds in treatment of type-2 diabetes mellitus patients. J Ethnopharmacol. 2011;137(1):643-651. doi:10.1016/j.jep.2011.06.020
36. Rose (Rosa damascena)
ع: الورد الدمشقي | ע: ורד דמשקאי
- Boskabady MH et al. Pharmacological effects of Rosa damascena. Iran J Basic Med Sci. 2011;14(4):295-307.
- Mahboubi M. Rosa damascena as holy ancient herb with novel applications. J Tradit Complement Med. 2016;6(1):10-16. doi:10.1016/j.jtcme.2015.09.005
37. Rosemary (Rosmarinus officinalis / Salvia rosmarinus)
ع: إكليل الجبل | ע: רוזמרין
- European Medicines Agency. Assessment report on Rosmarinus officinalis L., folium. EMA/HMPC/131100/2012. 2014.
- Moss M et al. Aromas of rosemary and lavender essential oils differentially affect cognition and mood in healthy adults. Int J Neurosci. 2003;113(1):15-38. doi:10.1080/00207450390161903
- Pengelly A et al. Short-term study on the effects of rosemary on cognitive function in an elderly population. J Med Food. 2012;15(1):10-17. doi:10.1089/jmf.2011.0005
- ESCOP Monographs: Rosmarini folium (Rosemary leaf). 2nd ed. Stuttgart: Thieme; 2003.
38. Sage (Three-lobed) (Salvia fruticosa / Salvia officinalis)
ع: المريمية | ע: מרווה משולשת
- European Medicines Agency. Assessment report on Salvia officinalis L., folium. EMA/HMPC/150801/2015. 2016.
- Lopresti AL. Salvia (sage): a review of its potential cognitive-enhancing and protective effects. Drugs R D. 2017;17(1):53-64. doi:10.1007/s40268-016-0157-5
- ESCOP Monographs: Salviae officinalis folium (Sage leaf). 2nd ed. Stuttgart: Thieme; 2003.
39. Sticky Fleabane (Dittrichia viscosa / Inula viscosa)
ع: الطيون | ע: בכורית קטנה
Note: Chemical and mechanistic data available; no human clinical trials conducted to date. Traditional use in Galilean folk medicine is well-documented.
- Zaccara S et al. Anti-inflammatory activity and chemical composition of Dittrichia viscosa. Nat Prod Res. 2016;30(14):1625-1629. doi:10.1080/14786419.2015.1055488
- Hernández V et al. A mechanistic approach to the in vivo anti-inflammatory activity of sesquiterpenoid compounds isolated from Inula viscosa. Planta Med. 2001;67(8):726-731. doi:10.1055/s-2001-18358
40. Stinging Nettle (Urtica dioica)
ع: القراص | ע: סרפד
- European Medicines Agency. Assessment report on Urtica dioica L., folium. EMA/HMPC/508015/2014. 2017.
- Safarinejad MR. Urtica dioica for treatment of benign prostatic hyperplasia: a prospective, randomized, double-blind, placebo-controlled, crossover study. J Herb Pharmacother. 2005;5(4):1-11. doi:10.1080/15228940500435206
- Mittman P. Randomized, double-blind study of freeze-dried Urtica dioica in the treatment of allergic rhinitis. Planta Med. 1990;56(1):44-47. doi:10.1055/s-2006-960881
- Commission E. Urticae folium. Bundesanzeiger 1989;164.
41. Sweet Almond (Prunus dulcis)
ع: اللوز الحلو | ע: שקד מתוק
- Wien M et al. Almond consumption and cardiovascular risk factors in adults with prediabetes. J Am Coll Nutr. 2010;29(3):189-197. doi:10.1080/07315724.2010.10719833
- Jamshed H et al. Dietary almonds increase serum HDL cholesterol in coronary artery disease patients in a randomized controlled trial. J Nutr. 2015;145(10):2287-2292. doi:10.3945/jn.114.207944
- Ahmad Z. The uses and properties of almond oil. Complement Ther Clin Pract. 2010;16(1):10-12. doi:10.1016/j.ctcp.2009.06.015
42. Turmeric (Curcuma longa)
ع: الكركم | ע: כורכום
- Daily JW, Yang M, Park S. Efficacy of turmeric extracts and curcumin for alleviating joint arthritis: a systematic review and meta-analysis of randomized clinical trials. J Med Food. 2016;19(8):717-729. doi:10.1089/jmf.2016.3705
- Hewlings SJ, Kalman DS. Curcumin: a review of its effects on human health. Foods. 2017;6(10):92. doi:10.3390/foods6100092
- Gupta SC, Patchva S, Aggarwal BB. Therapeutic roles of curcumin: lessons learned from clinical trials. AAPS J. 2013;15(1):195-218. doi:10.1208/s12248-012-9432-8
43. Watermelon (Citrullus lanatus)
ع: البطيخ الأحمر | ע: אבטיח
- Figueroa A et al. Effects of watermelon supplementation on blood pressure and wave reflection in prehypertensive and hypertensive adults. Am J Hypertens. 2011;24(1):40-44. doi:10.1038/ajh.2010.142
- Collins JK et al. Watermelon consumption increases plasma arginine concentrations in adults. Nutrition. 2007;23(3):261-266. doi:10.1016/j.nut.2007.01.005
44. Wheatgrass (Triticum aestivum)
ع: القمح | ע: עשב חיטה
Note: Clinical evidence for wheatgrass is limited to pilot studies. Use is based primarily on nutritional composition and traditional practice.
- Bar-Sela G et al. Wheat grass juice may improve hematological toxicity related to chemotherapy in breast cancer patients: a pilot study. Nutr Cancer. 2007;58(1):43-48. doi:10.1080/01635580701308083
45. White Mulberry (Morus alba)
ع: التوت الأبيض | ע: תות לבן
- Andallu B et al. Effect of mulberry therapy on plasma and erythrocyte membrane lipids in patients with type 2 diabetes. Clin Chim Acta. 2001;314(1-2):47-53. doi:10.1016/s0009-8981(01)00632-5
- Mudra M et al. Influence of mulberry leaf extract on the blood glucose response to ingestion of 75g sucrose by type 2 diabetic and control subjects. Diabetes Care. 2007;30(5):1272-1274. doi:10.2337/dc06-2120
- Kojima Y et al. Effects of mulberry leaf extract rich in 1-deoxynojirimycin on blood lipid profiles in humans. J Clin Biochem Nutr. 2010;47(2):155-161. doi:10.3164/jcbn.10-53
46. White Savory / Zuta (Micromeria fruticosa)
ع: الزوفا الصخرية | ע: קורנית מכחילה (זוטא)
Note: No species-specific clinical trials on Micromeria fruticosa exist. References below cover the broader Lamiaceae family and related genera with similar phytochemical profiles. Classified as ⚪ — traditional knowledge requiring further research.
- Sokovic MD et al. Chemical composition of essential oils of Thymus and Mentha species and their antifungal activities. Molecules. 2009;14(1):238-249. doi:10.3390/molecules14010238
- Formisano C, Rigano D, Senatore F. Chemical constituents and biological activities of Nepeta species. Chem Biodivers. 2011;8(10):1783-1818. doi:10.1002/cbdv.201000191 [Related genus within Lamiaceae family]
Foundational References
Regulatory Monographs
- European Medicines Agency (EMA). Committee on Herbal Medicinal Products (HMPC). Community herbal monographs. London: EMA; 2023. Available at: https://www.ema.europa.eu/en/committees/committee-herbal-medicinal-products-hmpc
- European Scientific Cooperative on Phytotherapy (ESCOP). ESCOP Monographs: The Scientific Foundation for Herbal Medicinal Products. 2nd ed. Stuttgart: Georg Thieme Verlag; 2003.
- World Health Organization (WHO). WHO monographs on selected medicinal plants. Geneva: WHO Press; 1999–2009. 4 volumes.
- Blumenthal M et al., editors. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Austin: American Botanical Council; 1998.
Professional Databases and Drug Interaction Resources
- Natural Medicines Database. Stockton (CA): Therapeutic Research Faculty; 2023. Available at: https://naturalmedicines.therapeuticresearch.com/
- Williamson EM, Driver S, Baxter K, editors. Stockley's Herbal Medicines Interactions. 2nd ed. London: Pharmaceutical Press; 2013.
Standard Pharmacognosy Textbooks
- Evans WC, Evans D, Trease GE. Trease and Evans' Pharmacognosy. 17th ed. Edinburgh: Saunders Elsevier; 2016.
- Bruneton J. Pharmacognosy, Phytochemistry, Medicinal Plants. 2nd ed. Paris: Lavoisier Publishing; 1999.